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Nevertheless, Doi was satisfied that the cooling system would grant an additional 41km/h (25mph) to the Ki-64 and battle damage would not significantly reduce the. With no ability to regain level flight from the plummeting Oka, Nagano was able to extract himself from the stricken aircraft but his parachute only partially. An Act-4(330-911)/GST-fusion protein, but not GST alone, was immunoprecipitated together with active PAI-1. In solid phase binding assays, active wild-type PAI-1 as well as the PAI-1 variant Q123K (which does not interact with multimeric Vn) was found to bind to Act-4(330-911)/GST. Latent PAI-1, latent Q123K, and the.
“Not the gun but the word is the symbol of authority.” Charles Lindblom, former American political scientist and economist. Public discussion and debate are essential in a social democracy such as Barbados. Indeed, effective political language and communication are healthy for good governance, especially in a context where there is a contest of alternative policies and programmes by competing political parties. There is a held view in Political Science that “politics without communication is like having blood without veins and arteries: it’s not really going anywhere.” Surely, Barbadians are prompted to ask what is the logic or intent of Prime Minister Freundel Stuart’s abysmal communication style?
Stuart’s intrinsic disinclination to engage the nation is problematic, and the lack of substance coming from the Democratic Labour Party (DLP) is taking Barbados nowhere favourable. While the policy orientations of the Ministers of Cabinet may have flowed from manifesto promises or to address Barbados’ systemic shortcomings, their discursive practices – contextually constructed phenomena reflecting their power positions – have singed the local landscape by being shambolic. The fact is, policy-making is a constant discursive struggle in which strategic communication is a prerequisite for national solutions. Political language fused into broader communication dynamics happens to be one of the main tools of policymaking.
Strategic political communication refers to a multiplicity of techniques that reach out to audiences to build and maintain relationships and, to coordinate activities that can mobilize supporters and rally the nation. This type of communication helps to persuade and/or convince the audience to actively support the efforts being articulated.
However, one must not fall into the trap of thinking that political communication and propaganda are one and the same thing. Propaganda is‘systematic strategic mass communication conveyed by an organization’ such as our political parties, to ‘shape perceptions and manipulate the cognitions of a specific audience’ so as to achieve the goal of directing ‘the audience’s behaviour to achieve a response that furthers the political objectives’ of the organization. It is not necessarily framed in or for the national interest, nor is it conducive to encouraging constructive criticism. By their definitions, political communication and propaganda can be informative. However, strategic communication will be inclusionary, but propaganda will not engender deliberation and participation.
Propaganda does not tolerate discussion and by its very nature, it rejects contradiction and discussion. The propagandist posturing evident in Barbados, is precisely the way Stuart and the DLP function. They have resorted more to propaganda than on fixing the problems which occurred under Stuart’s stewardship.
On the verge of what is expected to be a stubbornly fought general election, the language of politics will become more divisive, and increasingly unclear and conflicting. Numerous Barbadians have become aware that Stuart often reveals a greater propensity to scuttle national consensus-building than inspire through effective, transformational leadership. Stuart’s limited communication reveals that he can be utterly dismissive, thus producing disruptive national outcomes.
Popular discourse indicates that Barbadians in droves are ready to again express dissatisfaction with the current DLP Government. Simutech Troubleshooting Keygen Software. This displeasure goes beyond the previously held marches of protest and disgust. There are Barbadians hopeful of solace and are gravitating towards the inspiration of the Leader of the Opposition and the Barbados Labour Party (BLP).
To a lesser extent, small portions of the Barbados society are also drawn to emergent political entities. Noteworthy, is that the‘third’ political parties have no relevant or proven track record of performing and delivering in the national interest, although all things are possible. The next prime minister must seal a by far better deal for all Barbadians. Urgently required is an empathetic leader who will talk, can inspire, and will prioritize the needs of Barbados.
That leader must communicate a clear vision arising from nothing short of‘rubbing shoulders’ with the electorate and listening to the expectations and complaints of the nation. Barbadians are craving for truthful information.
Admittedly, Prime Minister Stuart means well, but he has been ineffective on leadership. He does not seek to motivate and enhance national performances or even productivity. Strategic and effective political communication has escaped his attention. Indiscipline within his Cabinet divulges the validity of that sentiment.
Furthermore, when there is necessity to inform Barbadians about the state’s priorities and the ills affecting society, or the means for achieving national goals, Stuart is frequently mute. Stuart’s breastplate overly relies on serendipity, while this conundrumis amplified by an ongoing mismatch between Stuart’s DLP as the key speakers and Barbadians as the listeners. There is definite gross misunderstanding between the expectations of the governed and the objectives of the governing. Stuart, invariably, buckles when it comes to utilizing and maximizing soft power. Soft power arises from factors such as consideration for traditions, drawing on local political culture, and inculcating the dominant values that would have emerged in the post-independence period. Stuart’s resistance to local value systems and attributes that were essential in guiding Barbados’ local practices and policies since 1966, regularly scuttles his ability to obtain the DLP’s vision of ‘continuing on the pathways to progress’.
Stuart’s woeful stance has redirected the DLP to becoming more autocratic while relishing on secrecy, coercion, and of course, propaganda. Why hasn’t Stuart seized the moment and the DLP utilize strategic communication and stakeholder deliberation as the means for igniting national reforms in governance? With strategic communication and the use of soft power, PM Stuart could have achieved many positive things for Barbados.
Surely, Barbadians are being short-changed by this DLP government. The hiatus in governance continues to widen due to the paltry efforts at communicating with the public. For example, it is true that Barbados ought to soon have a Teaching Service Commission. Yet, teachers have not had adequate input into the constitutive elements of this innovation. The void is likely to throw out another set of avoidable controversies for the DLP.
Stuart’s refusal to use soft power, also fosters resentment on taxation. The DLP is unlikely to overcome Barbadians’ rejection of the National Social Responsibility Levy (NSRL). The Finance Minister tersely pushed the NSRL up by 400% from its original two per cent, but last week, he boasted that the tax was raking in more than expected since implementation. Sinckler’s brag was followed by the lukewarm defence of Minister Donville Inniss, and retreat by Stuart. Surely, the $50 million in revenues are intended to enhance benefits for the people. With the credibility of the DLP near rock-bottom, how does one explain the authoritarian disdain?
Today, Barbadians still need to understand where the country’s economy lurks. How many more sacrifices will be necessary to stop the entire country from falling over the cliff?
Secrecy and surprise are normally essential weapons of war, but these are undermining Barbados’ social democracy. There can be no war among ourselves. Acting Governor of the Central Bank, Cleviston Haynes interestingly stated more than a year ago that: “We must bring new energy and bold strategies to the challenges which we all face. The real enemy is not each other, but unemployment, poverty and the need to renew our confidence in the Barbados economy.”. Important Jewels and Jadeite, Hong Kong, 12 Oct 2017, 02:00 PM comment5, Hitler, 454, Arms Production in the United Kingdom: Problems and Prospects, 9732, Heaven Knows, 062, Jumanji, ljrwar, Roads for the West Country, 3894, The Architecture of Europe,%-DD, Moose Country 2002 Calendar: 16 Month, 55533, At Home With the Word 2001: Sunday Scriptures and Reflections, >:-), We provide Training, Interview support (Male/Female) & Job support for almost all IT courses / technologies in market.
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Today, prescription and synthetic opioids crowd America’s medicine cabinets and streets, driving a modern crisis that may kill half a million people over the next decade. Image by Lead Pipe Productions Pty Ltd Doctors thought the syrup would be “non-addictive.” Instead, it turned into a More than 70 percent of the world’s opium — 3,410 tons — goes to heroin production, a number that has more than doubled since 1985. Approximately 17 million people around the globe used heroin, opium or morphine in 2016. Today, prescription and synthetic opioids crowd America’s medicine cabinets and streets, driving a modern crisis that. Opioids claimed 53,000 lives in the U.S. Last year, from the Centers for Disease Control and Prevention —.
How did we arrive here? Here’s a look at why our brains get hooked on opioids. The pain divide Let’s start with. They go by different names depending on which scientist you ask.
Peripheral versus central pain. Nociceptive versus neuropathic pain. The distinction is the sensation of actual damage to your body versus your mind’s perception of this injury. Your body quiets your pain nerves through the production of natural opioids called endorphins. Stuff that damages your skin and muscles — pin pricks and stove burns — is considered peripheral/nociceptive pain.
Pain fibers sense these injuries and pass the signal onto nerve cells — or neurons — in your spine and brain, the duo that makes up your central nervous system. In a normal situation, your pain fibers work in concert with your central nervous system. Someone punches you, and your brain thinks “ow” and tells your body how to react.
Stress-relieving hormones get released. Your immune system counteracts the inflammation in your wounded arm. New Jack Swing Gold Rar. Your body quiets your pain nerves through the production of natural opioids called endorphins. The trouble is when these pain pathways become overloaded or uncoupled. One receptor to rule them all Say you have chronic back pain.
Your muscles are inflamed, constantly beaming pain signals to your brain. Your natural endorphins aren’t enough and your back won’t let up, so your doctor prescribes an opioid painkiller like oxycodone. Prescription opioids and natural endorphins both land on tiny docking stations — called receptors — at the ends of your nerves. Most receptors catch chemical messengers — called neurotransmitters — to activate your nerve cells, triggering electric pulses that carry the signal forward. The Mu-opiate receptor is responsible for the major effects of all opiates, whether it’s heroin, prescription pills like oxycodone or synthetic opioids like fentanyl.
The Mu-opiate receptor is responsible for the major effects of all opiates, whether it’s heroin, prescription pills like oxycodone or synthetic opioids like fentanyl, said Chris Evans, director of Brain Research Institute at UCLA. “The depression, the analgesia [pain numbing], the constipation and the euphoria — if you take away the Mu-opioid receptor, and you give morphine, then you don’t have any of those effects,” Evans said.
Opioids receptors trigger such widespread effects because they govern more than just pain pathways. When opioid drugs infiltrate a part of, their receptors slow respiration, cause constipation, lower blood pressure and decrease alertness., where opioids receptors switch off a batch of nerve cells called GABAergic neurons. GABAergic neurons are themselves an off-switch for the brain’s euphoria and pleasure networks. When it comes to addiction, opioids are an off-switch for an off-switch. Opioids hold back GABAergic neurons in the midbrain, which in turn keep another neurotransmitter called dopamine from flooding a brain’s pleasure circuits. Image by Adam Sarraf Once opioids shut off GABAergic neurons, the pleasure circuits fill with another neurotransmitter called dopamine. At one stop on this pleasure highway — the nucleus accumbens — dopamine triggers a surge of happiness.
When the dopamine rolls into amygdala, the brain’s fear center, it relieves anxiety and stress. Both of these events reinforce the idea that opioids are rewarding. These areas of the brain are constantly communicating with decision-making hubs in the prefrontal cortex, which make value judgments about good and bad. When it hears “This pill feels good. Let’s do more,” the mind begins to develop habits and cravings. Taking the drug soon becomes second nature or habitual, Evans said, much like when your mind zones out while driving home from work.
The decision to seek out the drugs, rather than participate in other life activities, becomes automatic. The opioid pendulum: When feeling good starts to feel bad.
It is the surge of withdrawal from opioids that makes the drugs so inescapable. Opioid addiction becomes entrenched after a person’s neurons adapt to the drugs. The GABAergic neurons and other nerves in the brain still want to send messages, so they begin to adjust. They produce three to four times more cyclic AMP, a compound that primes the neuron to fire electric pulses, said Thomas Kosten, director of the division of alcohol and addiction psychiatry at the Baylor College of Medicine. That means even when you take away the opioids, Kosten says, “the neurons fire extensively.” The pendulum swings back. Now, rather than causing constipation and slowing respiration, the brain stem triggers diarrhea and elevates blood pressure.
Instead of triggering happiness, the nucleus accumbens and amygdala reinforce feelings of dysphoria and anxiety. All of this negativity feeds into the prefrontal cortex, further pushing a desire for opioids.
While other drugs like cocaine and alcohol can also feed addiction through the brain’s pleasure circuits, it is the surge of withdrawal from opioids that makes the drugs so inescapable. Could opioid addiction be driven in part by people’s moods? Chronic pain patients have a very high risk of becoming addicted to opioids if they are also coping with a mood disorder. Photo by Roy Morsch/via Getty Cathy Cahill, a pain and addiction researcher at UCLA, said these big swings in emotions likely factor into the, especially with those with chronic pain. A person with opioid use disorder becomes preoccupied with the search for the drugs. Certain contexts become triggers for their cravings, and those triggers start overlapping in their minds.
“The basic view is some people start with the pain trigger [the chronic back problem], but it gets partially substituted with the negative reinforcement of the opioid withdrawal,” Cahill said. That’s why Cahill, Evans and other scientists think the opioid addiction epidemic might be driven, in part, by our moods.
Patients on morphine experience 40 percent less pain relief from the drug if they have mood disorder. Chronic pain patients have a very high risk of becoming addicted to opioids if they are also coping with a mood disorder. A 2017 study — 81 percent — whose addiction started with a chronic pain problem also had a mental health disorder. Another found patients on morphine experience 40 percent less pain relief from the drug if they have mood disorder. They need more drugs to get the same benefits. People with mood disorders alone are also more likely to abuse opioids. A 2012 survey found patients with depression.
“So, not only does a mood disorder affect a person’s addiction potential, but it also influences if the opioids will successfully treat their pain,” Cahill said. Meanwhile, the country is living through sad times.
Some research suggests social isolation. While the opioid epidemic started long before the recession, with every 1 percent increase in unemployment. Can the brain swing back?
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As an opioid disorder progresses, a person needs a higher quantity of the drugs to keep withdrawal at bay. A person typically overdoses when they take so much of the drug that the brain stem slows breathing until it stops, Kosten said. Many physicians have turned to opioid replacement therapy, a technique that swaps highly potent and addictive drugs like heroin with compounds like methadone or buprenorphine (an ingredient in Suboxone). These substitutes outcompete heroin when they reach the opioid receptors, but do not activate the receptors to the same degree. By doing so, they reduce a person’s chances for overdosing.
These replacement medications also stick to the receptors for a longer period of time, which curtails withdrawal symptoms. Buprenorphine, for instance, while morphine only hangs on for a few milliseconds.
Science correspondent Miles O’Brien discovers future pain treatments may rely on virtual reality. For some, this solution is not perfect. The patients need to remain on the replacements for the foreseeable future, and some recovery communities.
Plus, opioid replacement therapy does not work for fentanyl, the synthetic opioid. Kosten’s lab is one of many working on a opioid vaccine that would direct a person’s immune system to clear drugs like fentanyl before they can enter the brain. But those are. And Evans and Cahill said many clinics in Southern California are combining psychological therapy with opioid replacement prescriptions to combat the mood aspects of the epidemic. “I don’t think there’s going to be a magic bullet on this one,” Evans said. “It’s really an issue of looking after society and looking after of people’s psyches rather than just treatment.” The post appeared first on. Manager of Litigation Support and eDiscovery Duties: Manage and support all litigation and technological services and requirements for the delivery of advocacy and dispute resolution services involving electronically stored information and eDiscovery.
Preparing paperless workflows; Identifying, purchasing and implementing new technology beneficial to paperless workflows; Working directly with IT and. The demand in the smart toys market, a sector born out of industrial and technological convergence, is projected for an impressive CAGR during the forecast period of 2017 to 2022. Albany, NY -- () -- -- A fresh market study by the researchers at Transparency Market Research (TMR) reports that the global smart toys market is heavily dependent on product innovation, and that an increasing number of players are venturing into the competitive landscape, eating out significant chunk of the total shares. That being said, a few companies do hold a respectable position in the global smart toys market, such as Activision Blizzard Inc., Fisher-Price Inc., The Hasbro Inc., LeapFrog Enterprises, Inc., Spin Master Corp, Seebo Interactive Ltd, Wow Wee Group Ltd, Genesis Toy Co. Ltd, Reach Robotics Ltd, and SmartGurlz ApS. While Activision Blizzard is a little ahead of the curve, Hasbro is concentrating on revisiting the most popular toys and games. LEGO too has made heavy investments for research and development in the recent past to emerge as a notable competitor in the global smart toys market.
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View and Download TOC of Smart Toys Market Research Report@ Nascent Market Has Strong Potential for Product Innovation The demand in the smart toys market, a sector born out of industrial and technological convergence, is projected for an impressive CAGR during the forecast period of 2017 to 2022. However, the market for smart toys is still at its early stage, with Sphero BB8 App-Enabled Droid being the only one that has achieved broad consumer appeal in the toys to life segment.
In the near future, currently ongoing R&D efforts by the market leaders is expected to bear fruits and newer products are anticipated to make an impression on a wider population. That is when the demand in the global smart toys market will witness an escalation. Based on toy-type, the global smart toys market gains maximum demand for voice or image recognition toys, accounting for US$2,271.7 mn in 2017 and projected for a CAGR of 3.7% during the forecast period of 2017 to 2022. This segment is growing at US$ 89.7 mn annually over the course of the forecast period, and this absolute growth is larger than the any other segment, viz. Request and Download Sample Report@ App-enabled mechanical toys, screenless toys, toys-to-life, puzzles and building games, health tracking toys, wearables, and others. North America is identified as the most lucrative regional market for smart toys, promising a revenue worth US$2,119.2 mn by 2022.
On the other hand, the demand for smart toys in the region of Asia Pacific expect Japan (APEJ) is anticipated to expand at an above-average CAGR of 3.9% during the same forecast period. Increased Disposable Income of Urban Population Driving Demand Urban population is growing increasing inclined towards restless lifestyle and while they have managed to add to their disposable income, time for personalized parenting is diminishing.
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Smart toys utilize artificial intelligence, and are punctuated with microprocessors, input and output devices, and volatile or nonvolatile memory units. Smart toys goes beyond just being educational toys, as they can recognize speech as well as react to their surroundings in order to provide a comprehensive entertainment and engagement to children between the age group of five to 14. The growth of the global smart toys market is also a reflection of increasing awareness towards the smart toys and the availability of diverse indoor and outdoor sports and educational toys. On the other hand, high cost of these products, the lack of awareness among large masses, particularly in the emerging economies, regulatory issues for overseas distribution, and impending innovations are some of the challenges that are hindering the prosperity of the global smart toys market. The emergence of the Internet of Things (IoT) is having tremendous positive effect on the global smart toys market too. With IoT, modern toys are increasingly becoming a potential area wherein connectivity and existing toy types can be collaborated together to innovate appealing new devices, referred to as connected or 'smart toys'.